Búsqueda | Biblioteca Virtual en Salud Fronteriza

1.

Disease-specific tau filaments assemble via polymorphic intermediates.

Lövestam, Sofia; Li, David; Wagstaff, Jane L; Kotecha, Abhay; Kimanius, Dari; McLaughlin, Stephen H; Murzin, Alexey G; Freund, Stefan M V; Goedert, Michel; Scheres, Sjors H W.

Nature ; 625(7993): 119-125, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-38030728

2.

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.

Gong, Grace Q; Bilanges, Benoit; Allsop, Ben; Masson, Glenn R; Roberton, Victoria; Askwith, Trevor; Oxenford, Sally; Madsen, Ralitsa R; Conduit, Sarah E; Bellini, Dom; Fitzek, Martina; Collier, Matt; Najam, Osman; He, Zhenhe; Wahab, Ben; McLaughlin, Stephen H; Chan, A W Edith; Feierberg, Isabella; Madin, Andrew; Morelli, Daniele; Bhamra, Amandeep; Vinciauskaite, Vanesa; Anderson, Karen E; Surinova, Silvia; Pinotsis, Nikos; Lopez-Guadamillas, Elena; Wilcox, Matthew; Hooper, Alice; Patel, Chandni; Whitehead, Maria A; Bunney, Tom D; Stephens, Len R; Hawkins, Phillip T; Katan, Matilda; Yellon, Derek M; Davidson, Sean M; Smith, David M; Phillips, James B; Angell, Richard; Williams, Roger L; Vanhaesebroeck, Bart.

Nature ; 618(7963): 159-168, 2023 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-37225977

3.

The IRE1ß-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells.

Neidhardt, Lisa; Cloots, Eva; Friemel, Natalie; Weiss, Caroline A M; Harding, Heather P; McLaughlin, Stephen H; Janssens, Sophie; Ron, David.

EMBO J ; 43(5): 719-753, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38177498

4.

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome.

Yan, Kaige; Yang, Jing; Zhang, Ziguo; McLaughlin, Stephen H; Chang, Leifu; Fasci, Domenico; Ehrenhofer-Murray, Ann E; Heck, Albert J R; Barford, David.

Nature ; 574(7777): 278-282, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-31578520

5.

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

Elliott, Paul R; Leske, Derek; Hrdinka, Matous; Bagola, Katrin; Fiil, Berthe K; McLaughlin, Stephen H; Wagstaff, Jane; Volkmar, Norbert; Christianson, John C; Kessler, Benedikt M; Freund, Stefan M V; Komander, David; Gyrd-Hansen, Mads.

Mol Cell ; 63(6): 990-1005, 2016 09 15.

Artículo en Inglés | MEDLINE | ID: mdl-27591049

6.

An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.

Perera, Luke A; Rato, Claudia; Yan, Yahui; Neidhardt, Lisa; McLaughlin, Stephen H; Read, Randy J; Preissler, Steffen; Ron, David.

EMBO J ; 38(21): e102177, 2019 10 04.

Artículo en Inglés | MEDLINE | ID: mdl-31531998

7.

Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1.

Fischer, Elyse S; Yu, Conny W H; Bellini, Dom; McLaughlin, Stephen H; Orr, Christian M; Wagner, Armin; Freund, Stefan M V; Barford, David.

EMBO Rep ; 22(7): e52242, 2021 07 05.

Artículo en Inglés | MEDLINE | ID: mdl-34013668

8.

SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses.

Carnell, George W; Ciazynska, Katarzyna A; Wells, David A; Xiong, Xiaoli; Aguinam, Ernest T; McLaughlin, Stephen H; Mallery, Donna; Ebrahimi, Soraya; Ceron-Gutierrez, Lourdes; Asbach, Benedikt; Einhauser, Sebastian; Wagner, Ralf; James, Leo C; Doffinger, Rainer; Heeney, Jonathan L; Briggs, John A G.

J Virol ; 95(15): e0020321, 2021 07 12.

Artículo en Inglés | MEDLINE | ID: mdl-33963055

9.

Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.

Stoll, Guido A; Oda, Shun-Ichiro; Chong, Zheng-Shan; Yu, Minmin; McLaughlin, Stephen H; Modis, Yorgo.

Proc Natl Acad Sci U S A ; 116(30): 15042-15051, 2019 07 23.

Artículo en Inglés | MEDLINE | ID: mdl-31289231

10.

Activation of GCN2 by the ribosomal P-stalk.

Inglis, Alison J; Masson, Glenn R; Shao, Sichen; Perisic, Olga; McLaughlin, Stephen H; Hegde, Ramanujan S; Williams, Roger L.

Proc Natl Acad Sci U S A ; 116(11): 4946-4954, 2019 03 12.

Artículo en Inglés | MEDLINE | ID: mdl-30804176

11.

Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study.

López-Méndez, Blanca; Baron, Bruno; Brautigam, Chad A; Jowitt, Thomas A; Knauer, Stefan H; Uebel, Stephan; Williams, Mark A; Sedivy, Arthur; Abian, Olga; Abreu, Celeste; Adamczyk, Malgorzata; Bal, Wojciech; Berger, Sylvie; Buell, Alexander K; Carolis, Carlo; Daviter, Tina; Fish, Alexander; Garcia-Alai, Maria; Guenther, Christian; Hamacek, Josef; Holková, Jitka; Houser, Josef; Johnson, Chris; Kelly, Sharon; Leech, Andrew; Mas, Caroline; Matulis, Daumantas; McLaughlin, Stephen H; Montserret, Roland; Nasreddine, Rouba; Nehmé, Reine; Nguyen, Quyen; Ortega-Alarcón, David; Perez, Kathryn; Pirc, Katja; Piszczek, Grzegorz; Podobnik, Marjetka; Rodrigo, Natalia; Rokov-Plavec, Jasmina; Schaefer, Susanne; Sharpe, Tim; Southall, June; Staunton, David; Tavares, Pedro; Vanek, Ondrej; Weyand, Michael; Wu, Di.

Eur Biophys J ; 50(3-4): 411-427, 2021 May.

Artículo en Inglés | MEDLINE | ID: mdl-33881594

12.

Atomic structure of the APC/C and its mechanism of protein ubiquitination.

Chang, Leifu; Zhang, Ziguo; Yang, Jing; McLaughlin, Stephen H; Barford, David.

Nature ; 522(7557): 450-454, 2015 Jun 25.

Artículo en Inglés | MEDLINE | ID: mdl-26083744

13.

The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism.

Buckles, Thomas C; Ohashi, Yohei; Tremel, Shirley; McLaughlin, Stephen H; Pardon, Els; Steyaert, Jan; Gordon, Moshe T; Williams, Roger L; Falke, Joseph J.

Biophys J ; 119(11): 2205-2218, 2020 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-33137306

14.

Equilibrium Binding Model for CpG DNA-Dependent Dimerization of Toll-like Receptor 9 Ectodomain.

Reikine, Stephanie; McLaughlin, Stephen H; Modis, Yorgo.

Biochemistry ; 59(43): 4155-4162, 2020 11 03.

Artículo en Inglés | MEDLINE | ID: mdl-32818369

15.

Molecular architecture and mechanism of the anaphase-promoting complex.

Chang, Lei-Fu; Zhang, Ziguo; Yang, Jing; McLaughlin, Stephen H; Barford, David.

Nature ; 513(7518): 388-393, 2014 Sep 18.

Artículo en Inglés | MEDLINE | ID: mdl-25043029

16.

A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.

Stowell, James A W; Wagstaff, Jane L; Hill, Chris H; Yu, Minmin; McLaughlin, Stephen H; Freund, Stefan M V; Passmore, Lori A.

J Biol Chem ; 293(24): 9210-9222, 2018 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-29695507

17.

Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae.

Aibara, Shintaro; Gordon, James M B; Riesterer, Anja S; McLaughlin, Stephen H; Stewart, Murray.

Nucleic Acids Res ; 45(3): 1529-1538, 2017 02 17.

Artículo en Inglés | MEDLINE | ID: mdl-28180315

18.

Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.

Wolf, Jana; Valkov, Eugene; Allen, Mark D; Meineke, Birthe; Gordiyenko, Yuliya; McLaughlin, Stephen H; Olsen, Tayla M; Robinson, Carol V; Bycroft, Mark; Stewart, Murray; Passmore, Lori A.

EMBO J ; 33(14): 1514-26, 2014 Jul 17.

Artículo en Inglés | MEDLINE | ID: mdl-24872509

19.

The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity.

Glas, Marjolein; van den Berg van Saparoea, H Bart; McLaughlin, Stephen H; Roseboom, Winfried; Liu, Fan; Koningstein, Gregory M; Fish, Alexander; den Blaauwen, Tanneke; Heck, Albert J R; de Jong, Luitzen; Bitter, Wilbert; de Esch, Iwan J P; Luirink, Joen.

J Biol Chem ; 290(35): 21498-509, 2015 Aug 28.

Artículo en Inglés | MEDLINE | ID: mdl-26160297

20.

Correction to: Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study.

López-Méndez, Blanca; Baron, Bruno; Brautigam, Chad A; Jowitt, Thomas A; Knauer, Stefan H; Uebel, Stephan; Williams, Mark A; Sedivy, Arthur; Abian, Olga; Abreu, Celeste; Adamczyk, Malgorzata; Bal, Wojciech; Berger, Sylvie; Buell, Alexander K; Carolis, Carlo; Daviter, Tina; Fish, Alexander; Garcia-Alai, Maria; Guenther, Christian; Hamacek, Josef; Holková, Jitka; Houser, Josef; Johnson, Chris; Kelly, Sharon; Leech, Andrew; Mas, Caroline; Matulis, Daumantas; McLaughlin, Stephen H; Montserret, Roland; Nasreddine, Rouba; Nehmé, Reine; Nguyen, Quyen; Ortega-Alarcón, David; Perez, Kathryn; Pirc, Katja; Piszczek, Grzegorz; Podobnik, Marjetka; Rodrigo, Natalia; Rokov-Plavec, Jasmina; Schaefer, Susanne; Sharpe, Tim; Southall, June; Staunton, David; Tavares, Pedro; Vanek, Ondrej; Weyand, Michael; Wu, Di.

Eur Biophys J ; 50(8): 1159-1160, 2021 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-34652497

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